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Johanna M Seddon Selected Research

chemotactic factor inactivator

10/2022Functional analysis of rare genetic variants in complement factor I in advanced age-related macular degeneration.
7/2015Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels.
11/2013Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.
7/2012Genetic factors for choroidal neovascularization associated with high myopia.
2/2011ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration.

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Johanna M Seddon Research Topics

Disease

46Macular Degeneration (Age-Related Maculopathy)
10/2022 - 12/2002
12Geographic Atrophy
11/2016 - 04/2005
8Eye Diseases (Eye Disease)
12/2020 - 02/2004
6Genetic Predisposition to Disease (Genetic Predisposition)
11/2020 - 01/2006
6Retinoblastoma (Glioblastoma, Retinal)
12/2019 - 04/2005
5Neoplasms (Cancer)
01/2019 - 08/2004
5Cardiovascular Diseases (Cardiovascular Disease)
05/2012 - 02/2004
3Cataract (Cataracts)
09/2016 - 08/2004
2Disease Progression
12/2020 - 12/2011
2Sarcoma (Soft Tissue Sarcoma)
12/2019 - 01/2007
2Hypertension (High Blood Pressure)
10/2011 - 04/2006
2Retinal Detachment (Retinal Detachments)
02/2006 - 04/2005
2Choroidal Neovascularization
02/2006 - 04/2005
1Inflammation (Inflammations)
12/2020
1Infections
12/2020
1COVID-19
12/2020
1Genetic Risk Score
11/2020
1Atrophy
11/2016
1Open-Angle Glaucoma (Glaucoma, Open Angle)
09/2016
1Glaucoma
09/2016
1Exfoliation Syndrome
09/2016
1Obesity
05/2014
1Myopia
07/2012
1Atypical Hemolytic Uremic Syndrome
10/2011
1Albuminuria
10/2011
1Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)
10/2011
1Kidney Diseases (Kidney Disease)
10/2011
1Type 2 Diabetes Mellitus (MODY)
06/2011
1Macular Edema
06/2010
1Retinal Drusen
02/2006
1Blindness (Hysterical Blindness)
01/2006

Drug/Important Bio-Agent (IBA)

8Complement Factor H (Factor H)IBA
12/2016 - 01/2006
8AntioxidantsIBA
12/2016 - 02/2004
5chemotactic factor inactivatorIBA
10/2022 - 02/2011
5Complement System Proteins (Complement)IBA
12/2020 - 10/2007
4ZincIBA
12/2016 - 04/2005
4Biomarkers (Surrogate Marker)IBA
07/2015 - 06/2005
4LipidsIBA
05/2012 - 06/2005
4C-Reactive ProteinIBA
08/2010 - 02/2004
3Vitamin DFDA LinkGeneric
10/2017 - 07/2011
3Carotenoids (Carotene)IBA
09/2016 - 06/2004
3Complement C2 (Complement Component 2)IBA
04/2016 - 09/2012
3Complement Factor B (Factor B)IBA
04/2016 - 09/2012
3Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
05/2013 - 07/2006
3LuteinIBA
11/2010 - 01/2007
3Lipase (Acid Lipase)FDA Link
11/2010 - 04/2010
3VitaminsIBA
01/2007 - 02/2004
2Complement Factor I (C3b Inactivator)IBA
10/2022 - 07/2015
2Complement C3 (C3 Complement)IBA
04/2016 - 11/2015
2Collagen Type VIIIIBA
04/2016 - 11/2015
2High-Temperature Requirement A Serine Peptidase 1IBA
04/2016 - 11/2015
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2016 - 05/2012
2DNA (Deoxyribonucleic Acid)IBA
10/2015 - 12/2009
2Dietary Fats (Dietary Fat)IBA
05/2014 - 12/2003
2Apolipoproteins E (ApoE)IBA
12/2011 - 06/2011
2HDL LipoproteinsIBA
10/2010 - 04/2010
2Retinaldehyde (Retinal)IBA
06/2010 - 12/2003
2Ascorbic Acid (Vitamin C)FDA LinkGeneric
09/2007 - 01/2007
2ZeaxanthinsIBA
09/2007 - 01/2007
2Vitamin EFDA LinkGeneric
01/2007 - 04/2006
2HomocysteineIBA
04/2006 - 01/2006
1Retinal Pigments (Pigments, Visual)IBA
11/2016
1poly(dG-dA)n.poly(dC-dT)n (((GA)n))IBA
05/2016
1Folic Acid (Vitamin M)FDA LinkGeneric
04/2016
1Vitamin B Complex (B Vitamins)IBA
04/2016
1Fibrinogen (Factor I)FDA Link
07/2015
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
08/2013
1Dihydrotachysterol (AT 10)IBA
04/2013
1Genetic Markers (Genetic Marker)IBA
05/2012
1P-2 (P 2)IBA
12/2011
1Complement Factor D (Factor D)IBA
11/2011
1LigandsIBA
10/2011
1CholesterolIBA
10/2011
1Betaine (C.B.B.)FDA Link
07/2011
1Methionine (L-Methionine)FDA Link
07/2011
1Protein Isoforms (Isoforms)IBA
06/2011
1insulin receptor-related receptor (IRR)IBA
06/2011
1HDL CholesterolIBA
10/2010
1Metalloproteases (Metalloproteinases)IBA
04/2010
1Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
09/2008
1Vitamin A (Retinol)FDA LinkGeneric
09/2007
1alpha-TocopherolFDA Link
09/2007
1cupric oxide (copper oxide (CuO))IBA
01/2007
1beta Carotene (Betacarotene)FDA Link
01/2007
1Conjugated (USP) Estrogens (Premarin)FDA Link
07/2006
1Hormones (Hormone)IBA
07/2006
1Progestins (Progestagens)IBA
07/2006
1alpha-caroteneIBA
04/2006
1Vitamin B 6IBA
04/2006
1Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA
06/2005
1Lipoprotein(a)IBA
06/2005
1ApolipoproteinsIBA
06/2005
1Interleukin-6 (Interleukin 6)IBA
06/2005

Therapy/Procedure

7Radiotherapy
12/2019 - 04/2005
3Cataract Extraction
09/2016 - 08/2004
2Mediterranean Diet
11/2020 - 11/2015
2Drug Therapy (Chemotherapy)
01/2019 - 10/2014
2Therapeutics
04/2013 - 07/2006
1Intraocular Injections
05/2012
1Slit Lamp
02/2006